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V. P. Kahale ¹, P. R. Upadhay ¹, A. J. Mhaiskar ¹, P. S. Shelat ¹, D. R. Mundhada ¹

Affiliations
1 Department of Pharmacology, Agnihotri College of Pharmacy, Wardha, IN

Abstract

The core finding of the present study is that administration of relevant doses of Ruin is remarkably neuroprotective in rats against 6-Hydroxydopamine induced neurotoxicity. Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with multiple motor and non-motor features that contribute to the impairment of health-related quality of life (QOL). It is characterized by reduced movement, rigidity, and tremor. It is characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta. Rutin (3,3',4',5,7-pentahydroxyflavone-3-rhamnoglucoside) was a citrus flavonoid glycoside. Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. It act as a antioxidant and can prevent injury caused by reactive oxygen species (ROS) in various ways. Rutin was found to be a neuroprotective agent. Rutin was identified as the major LDL antioxidant compound of mulberry in an in vitro study. Rutin acts as a memory enhancer and an anti-oxidant Rutin treatment protects behavioral changes, and significantly attenuated oxidative damage and improved mitochondrial complexes enzyme activities in different regions (striatum, cortex and hippocampus) of rat brain against 6-OHDA induced neurotoxicity. I.C.V. administration of 6-Hydroxydopamine is known to produce hypoactivity that resembles juvenile onset and advanced Parkinson's disease in rats. The results show that Rutin treatment is effective in various behavioural models, thus it could be used as an effective therapeutic agent in the management of Parkinson's disease and related conditions. We attempted to investigate the neuroprotective effect of Rutin in animal model of Parkinson's disease, and thus it shows the effect of Rutin on 6-hydroxydopamine onduced memory impairment in Parkinson's disease in Rodents.

Keywords

6-OHDA, I.C.V., Parkinson Disease, Memory Impairment, Rutin.

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D. R. Mundhada ¹, A. V. Chandewar ¹

Affiliations
1 P. Wadhawani College of Pharmacy, Yeotmal, IN

Abstract

The present study described the gelation temperature, gelation time, viscosity study, pH, properties of thermosensitive gel prepared of poloxamer 407 and carbopol 934P which are not affected by the concentration of each component. i.e. addition of Drugs or reference catanionic mixture. The use of Catanionic drug-surfactant mixtures was proven to be an efficient novel method of obtaining sustained drug release from Insitu gels. The effects of changes in the pH and ionic strength on the catanionic aggregates was also investigated, and this method of sustaining the release was found to be quite resilient to variations in both. Although the phase behavior was somewhat affected, large micelles and vesicles were still readily found. The drug release was significantly sustained even under NaCl. Comparing the diffusion coefficients for drugs being released from gels with those for drugs from catanionic mixtures in gels revealed differences in the order of magnitude of 10 to 100. This means that the release of a drug can be extended over time, for example, from 30 minutes to 12 hours, potentially improving both the efficiency of the formulation and the patient compliance.

Keywords

Catanionic Drug-surfactant Mixtures, Gelation Temperature, Gelation Time, Viscosity Study, Poloxamer 407, Carbopol 934P.

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D. R. Mundhada ¹, A. V. Chandewar ¹

Affiliations
1 P. Wadhwani College of Pharmacy, Yeotmal, IN

Abstract

In-Situ Gel Delivery System In situ gelation is a process of gel formation at the site of action after the formulation has been applied at the site. Insitu gel phenomenon based upon liquid solution of drug formulation and converted into semi-solid mucoadhesive key depot. It permits the drug must be delivered in a liquid form or solution form.

Keywords

In-Situ Gel, Mucoadhesive, Depot.

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D. R. Mundhada ¹, A. V. Chandewar ¹

Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, IN

Abstract

Surfactants are compounds that lower the surface tension (or interfacial tension) between two liquids or between a liquid and a solid. Cationic surfactants are basically soaps or detergents, in which the hydrophilic, or waterloving, end contains a positively-charged ion, or cation. Typical examples are trimethylalkylammonium chlorides, and the chlorides or bromides of benzalkonium and alkylpyridinium ions. All are examples of quats, so named because they all contain a quaternary ammonium ion.

Keywords

Surfactants, Surface Tension, Cationic Surfactants, Quaternary Ammonium Ion.

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